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            WHO女性器官腫瘤分類解讀1

            文章出處:責任編輯:作者:人氣:-發表時間:2018-01-10 16:43:00【

             1、新版結構與主要內容變化

            與舊版不同,新版按惡性腫瘤在前,良性腫瘤在后排序。將舊版鱗狀上皮腫瘤及其相關病變和前驅病變中的“相關病變”刪除。鱗狀細胞癌中刪除“角化棘皮瘤樣”、“伴有腫瘤巨細胞的”及“其他”三個亞型。與子宮頸一樣,采用SIL替換VIN系統,以VIN作為別名,保留dVIN名稱,并作為SIL新的亞型。良性鱗狀上皮病變欄目下,將纖維上皮性息肉(fibroepithelialpolyp,SP)改為“上皮間質息肉(fibroepithe lialstromalpolyp,FSP)”;刪除翻轉性毛囊角化病。腺上皮腫瘤及癌前病變中刪除“小細胞癌”及“移行細胞癌”。上皮性腫瘤中新增神經內分泌腫瘤(neuroendocrinetumour,NET)一個分類,與子宮頸不同,無低級別所列類癌及非典型類癌,將上述小細胞癌改為小細胞神經內分泌癌(smallcell neuroendocrinecarcinoma,SCNEC),與大細胞神經內分泌癌(largecellneuroendocrinecarcinoma,LCNEC)一起并列為高級別,同時將舊版其他腫瘤”欄目下的Merkel細胞腫瘤(Merkelcelltumour,MCT)也歸于其下。舊版刪除“其它腫瘤”一個大項,包括卵黃囊瘤、表皮樣囊腫及成熟性囊性畸胎瘤;同時新增一個大項為生殖細胞腫瘤,僅將原先其它腫瘤中的卵黃囊瘤保留。上皮性腫瘤中將與鱗狀上皮腫瘤及腺體腫瘤并列的皮膚附屬器腫瘤,包括:惡性汗腺腫瘤、皮脂腺癌、汗管瘤、結節狀汗腺瘤、毛發上皮瘤(trichoepithelioma,TE)、外毛根鞘瘤及其他,進行整體刪除。新版將皮膚隆突性纖維肉瘤的ICD O編碼由8832/3改為8832/1,即由惡性改成中間型(罕見轉移);將侵襲性血管黏液瘤(aggressive angiomyxoma,AAM)的ICD O編碼由8841/1改為8841/0,即由交界性改成良性,以與軟組織腫瘤分類相一致[3]。將舊版淋巴組織和造血組織腫瘤中的惡性淋巴瘤(特殊類型)及白血病(特殊類型)中的“惡性”及括號內的“特殊類型”取消,用髓系腫瘤代替白血病。以上變化即恢復了WHO(1994)第2版[4]的一些結構和術語,并融入了新進展。

             

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