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            熱門關鍵詞:tct耗材液基細胞處理試劑盒代理病理組織標本固定劑環保組織固定液

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            液基薄層細胞學檢測和高危型人乳頭狀瘤病毒檢測在宮頸癌及癌前病變篩查和預后判斷中的應用價值

            文章出處:責任編輯:作者:人氣:-發表時間:2017-10-10 15:17:00【

              摘要

              目的探討液基薄層細胞學檢測(TCT)和高危型人乳頭狀瘤病毒(HPV)檢測對宮頸癌及癌前病變篩查和預后判斷價值.方法選擇行宮頸病變篩查的5458例女性,行TCT、高危型HPV檢測及陰道鏡下宮頸活組織病理學檢查,分析TCT和高危型HPV檢測對宮頸癌及癌前病變的診斷價值及預后判斷價值.結果TCT陽性者和/或高危型HPV陽性者1153例,行陰道鏡下宮頸活組織病理學檢查發現,正常或慢性炎性反應592例,宮頸上皮內瘤變(CIN)Ⅰ338例,CINⅡ~Ⅲ196例,宮頸癌27例.其中高危型HPV陽性率隨宮頸病變程度的增加而增加,差異有統計學意義(P<0.05),宮頸癌患者宮頸分泌物中高危型HPV陽性率顯著高于CIN和正常或慢性炎性反應者,差異有統計學意義(P<0.01).以陰道鏡下宮頸活組織病理學檢查結果為標準,TCT聯合高危型HPV檢測特異度明顯高于單獨TCT和高危型HPV檢測[98.0%(580/592)比58.8%(348/592)、82.9%(491/592)],差異有統計學意義(P<0.05);TCT聯合高危型HPV檢測陽性預測值也明顯高于單獨TCT和高危型HPV檢測[96.2%(303/315)比67.4%(504/748)、76.9%(337/438)],差異有統計學意義(P<0.05).561例CIN和宮頸癌患者隨訪中發現術后34例患者病灶殘留或復發,以陰道鏡下宮頸活組織病理學檢查結果為標準,TCT聯合高危型HPV檢測特異度明顯高于單獨TCT和高危型HPV檢測[100.0%(527/527)比98.5%(519/527)、96.4%(508/527)],差異有統計學意義(P<0.01);TCT聯合高危型HPV檢測陽性預測值也明顯高于單獨TCT和高危型HPV檢測[100.0%(19/19)比78.9%(30/38)、57.8%(26/45)],差異有統計學意義(P<0.01).結論TCT聯合高危型HPV檢測的應用能有效地提高篩查結果的準確性,不僅有利于宮頸癌的早期診斷,而且對宮頸病變相關術后患者的預后具有重要的預測價值.(中山市康乃欣生物醫療科技有限公司摘錄)

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